%0 Journal Article
%T Identification of HLA-A24-Restricted Novel T Cell Epitope Peptides Derived from P-Cadherin and Kinesin Family Member 20A
%A Ryuji Osawa
%A Takuya Tsunoda
%A Sachiko Yoshimura
%A Tomohisa Watanabe
%A Motoki Miyazawa
%A Masaji Tani
%A Kazuyoshi Takeda
%A Hidewaki Nakagawa
%A Yusuke Nakamura
%A Hiroki Yamaue
%J Journal of Biomedicine and Biotechnology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/848042
%X We here identified human leukocyte antigen-(HLA-)A£¿2402-restricted epitope peptides from Cadherin 3, type 1, P-cadherin (CDH3) and kinesin family member 20A (KIF20A) that were found to be specifically expressed in cancer cells through genome-wide expression profile analysis. CDH3-10-807 peptide and KIF20A-10-66 peptide successfully induced specific CTL clones, and these selectively responded to COS7 cells expressing both HLA-A£¿2402 and respective protein while did not respond to parental cells or COS7 cells expressing either HLA-A£¿2402 or respective protein. Furthermore, CTL clones responded to cancer cells that endogenously express HLA-A£¿2402 and respective protein, suggesting that CDH3-10-807 peptide and KIF20A-10-66 peptide are naturally presented on HLA-A£¿2402 molecule of human cancer cells. Our results demonstrated that CDH3-10-807 peptide and KIF20A-10-66 peptide are novel HLA-A24-restricted tumor-associated antigens and would be applicable for CTL-inducing cancer therapies.
%U http://www.hindawi.com/journals/biomed/2012/848042/