%0 Journal Article
%T RNA G-quadruplexes and their potential regulatory roles in translation
%A Ivan Topisirovic
%A Jean-Pierre Perreault
%A Jingwen Song
%A St¨¦phane Richard
%J Archive of "Translation".
%D 2016
%R 10.1080/21690731.2016.1244031
%X DNA guanine (G)-rich 4-stranded helical nucleic acid structures called G-quadruplexes (G4), have been extensively studied during the last decades. However, emerging evidence reveals that 5¡ä- and 3¡ä-untranslated regions (5¡ä- and 3¡ä-UTRs) as well as open reading frames (ORFs) contain putative RNA G-quadruplexes. These stable secondary structures play key roles in telomere homeostasis and RNA metabolism including pre-mRNA splicing, polyadenylation, mRNA targeting and translation. Interestingly, multiple RNA binding proteins such as nucleolin, FMRP, DHX36, and Aven were identified to bind RNA G-quadruplexes. Moreover, accumulating reports suggest that RNA G-quadruplexes regulate translation in cap-dependent and -independent manner. Herein, we discuss potential roles of RNA G-quadruplexes and associated trans-acting factors in the regulation of mRNA translation
%K Aven
%K DHX36
%K FMRP
%K G-quadruplexes
%K RNA binding proteins
%K translation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173311/