%0 Journal Article %T Fermi-Bose Mixtures and BCS-BEC Crossover in High-Tc Superconductors %J Condensed Matter | An Open Access Journal from MDPI %D 2019 %R https://doi.org/10.3390/condmat4020051 %X In this review article we consider theoretically and give experimental support to the models of the Fermi-Bose mixtures and the BCS-BEC (Bardeen Cooper Schrieffer¨CBose Einstein) crossover compared with the strong-coupling approach, which can serve as the cornerstones on the way from high-temperature to room-temperature superconductivity in pressurized metallic hydrides. We discuss some key theoretical ideas and mechanisms proposed for unconventional superconductors (cuprates, pnictides, chalcogenides, bismuthates, diborides, heavy-fermions, organics, bilayer graphene, twisted graphene, oxide hetero-structures), superfluids and balanced or imbalanced ultracold Fermi gases in magnetic traps. We build a bridge between unconventional superconductors and recently discovered pressurized hydrides superconductors H 3S and LaH 10 with the critical temperature close to room temperature. We discuss systems with a line of nodal Dirac points close to the Fermi surface and superconducting shape resonances, and hyperbolic superconducting networks which are very important for the development of novel topological superconductors, for the energetics, for the applications in nano-electronics and quantum computations. View Full-Tex %U https://www.mdpi.com/2410-3896/4/2/51