%0 Journal Article
%T Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity
%A K Akhter
%A K Jahan
%A KR Khan
%A ME Halim
%A S Rifat
%A S Shefa
%A SM Ahmed
%A UKR Romman
%J Bangladesh Journal of Scientific and Industrial Research
%D 2019
%R https://doi.org/10.3329/bjsir.v54i1.40730
%X We report herein the use of nickel nitrate hexahydrate [Ni(NO3)2.6H2O] as a new catalyst for the one-pot Biginelli like reaction coupling of 1-phenyl thiourea, ethyl acetoacetate and aromatic aldehydes to afford the corresponding 1-phenyl-3,4-dihydropyrimidin-2(1H)-thiones under solvent free condition to avoid the usage of hazardous organic solvents. The synthesized compounds were evaluated for their antimicrobial activity by KIRBY-BAUER disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity
%U https://www.banglajol.info/index.php/BJSIR/article/view/40730