%0 Journal Article
%T The Renin-Angiotensin System: Is there a Limit to where it Goes?
%A Flavio de Castro Magalhaes
%J Biocoreopen
%D 2017
%R 10.25141/2575-8160-2017-1.0007
%X The renin angiotensin system (RAS) has been extensively studied since the Finnish physiologist Robert Tigerstedt described in 1898 that arterial pressure was elevated upon infusion of kidney extracts containing the a£¿£¿pressor substancea£¿£¿ renin in anesthetized animals[1]. Its understanding is of unquestionable relevance for the cardiovascular homeostais since pharmacological agents (a£¿£¿sartans (AT1R blockers) or a£¿£¿pril (ACE inhibitors)) that blunt actions of the RAS has been extensively used in the management of various cardiovascular conditions and its benefits goes beyond the blood pressure reduction effects[2]. More recently, therapeutical strategies have also reached the inhibition of upstream molecules as the discoveries of renin inhibitors
%U https://biocoreopen.org/ijch/The-Renin-Angiotensin-System-Is-there-a-limit-to-where-it-goes.php