%0 Journal Article
%T Paradigm shift in Discovery & Secretion of Biosimilars via path breaking Innovation
%A Pawan Saharan
%J Biocoreopen
%D 2017
%R 10.25141/2475-3432-2017-4.0080
%X Radha108 nano peptides stimulate the Cytotoxic T-cells of the innate immune system to naturally produce bio similars like cytokines (interleukins and interferons). Radha108 is proven to increase the production of these cytokines by 5 folds. These nano peptides get absorbed in the blood through buccal mucosa and have potential of crossing the blood brain barrier (BBB). Radha108 acts on pituitary gland that in turn promotes the differentiation of B cells, maturation of macrophages, monocytes and stimulates the production of cytokines IL-1 to IL-11, TNF-£¿¡À, INFa£¿£¿£¿3. It also helps in the maturation of immature thymocytes either into helper or suppressor T cells that help in priming bodya£¿£¿s immune system against infections and immune disorders like asthma, allergy, upper respiratory tract infection (URTI), carcinomas and type 2 diabetes thereby saving huge amount of resources and money that are spent in treating such ailments with little or no efficacy. Radha108 acts as a molecular signaling device which works through receptors on target cell surfaces. These nano-informational peptide proteins mitigate cell fusion by docking on the glycoprotein receptors present on the CD4+ and CD8+ T cells for Gp120, Gp180 and Gp160 thereby closing the entry of virus, foreign antigen and allergens. Radha 108 nano peptides SEQ ID 1-8 was extracted from bovine colostrum and has been granted the US patent (U.S. Patent No. 9,249,188 & 8,518,454 B2). These nano peptides consist of ELVPGVPRGTQL (DNA- binding Protein Inhibitor ID -3), VAIIQHMIKKLR (Epstein a£¿£¿ Barr virus induced gene-2), LPQEVLNENLLRF (Alpha S1- Casein), RLNARMAELR ( S-adenosylm ethionine synthetase isoform type -1), SSLQVLNMSHN( Toll- like receptor -4), EYQELMNVK (Keratin type II cytoskeletal 59kDa component IV), VDTLNDEINFLR (Keratin type II cytoskeletal 7), DGIVNENLAER ( Ribonucleoside a£¿£¿ diphosphate reductase small chain). Thus, Radha 108 nanopeptides stimulate the secretion of bio- similars (wide range of cytokines like interleukins and interferons) that are very effective in treating viral infections like HIV, cold, swine flu and immune disorders like allergy, asthma, arthritis, diarrhea, fatigue- malaise, anaemia, endometriosis by stimulating the cytotoxic T cells
%K Radha 108
%K Infection
%K PRP
%K Interferon
%K Cytokines
%U https://biocoreopen.org/ijbb/Paradigm-shift-in-discovery&secretion-of-Biosimilars-via-path-breaking.php