%0 Journal Article
%T Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients
%A Philip W. Connelly
%A Graham F. Maguire
%A Michelle M. Nash
%A Lindita Rapi
%A Andrew T. Yan
%A G. V. Ramesh Prasad
%J Journal of Lipids
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/608580
%X South Asian renal transplant recipients have a higher incidence of cardiovascular disease compared with Caucasian renal transplant recipients. We carried out a study to determine whether paraoxonase 1, a novel biomarker for cardiovascular risk, was decreased in South Asian compared with Caucasian renal transplant recipients. Subjects were matched two to one on the basis of age and sex for a total of 129 subjects. Paraoxonase 1 was measured by mass, arylesterase activity, and two-substrate phenotype assay. Comparisons were made by using a matched design. The frequency of PON1 QQ, QR and RR phenotype was 56%, 37%, and 7% for Caucasian subjects versus 35%, 44%, and 21% for South Asian subjects ( £¿ 2 = 7 . 7 2 , £¿£¿ = 0 . 0 2 ). PON1 mass and arylesterase activity were not significantly different between South Asian and Caucasian subjects. PON1 mass was significantly associated with PON1 phenotype ( £¿£¿ = 0 . 0 0 0 1 ), HDL cholesterol ( £¿ = 0 . 0 0 9 ), LDL cholesterol ( £¿£¿ = 0 . 0 2 ), and diabetes status ( £¿£¿ < 0 . 0 5 ). Arylesterase activity was only associated with HDL cholesterol ( £¿£¿ = 0 . 0 0 3 ). Thus the frequency of the PON1 RR phenotype was higher and that of the QQ phenotype was lower in South Asian versus Caucasian renal transplant recipients. However, ethnicity was not a significant factor as a determinant of PON1 mass or arylesterase activity, with or without analysis including PON1 phenotype. The two-substrate method for determining PON1 phenotype may be of value for future studies of cardiovascular complications in renal transplant recipients. 1. Introduction Kidney transplant recipients (KTRs) are known to be at increased risk for cardiovascular disease and by three years after transplant about 40% of KTRs have experienced a cardiovascular disease-related event [1]. The incidence of disease is occurring in the context of best medical practice for treatment of established cardiovascular risk factors. Thus there is a need to identify novel risk factors with the objective of improving treatment and reduction of the incidence of cardiovascular disease. End-stage renal disease, the precursor to KTR, is increasing in individuals of South Asian ethnicity relative to subjects of Caucasian ethnicity [1]. There is a need to characterize these subjects and determine whether novel risk factors for cardiovascular disease are present in an ethnicity-dependent manner. The current study was designed to compare two novel risk factors, adiponectin and paraoxonase 1 (PON1), as candidates for differing risk between South Asian and Caucasian KTR. We observed
%U http://www.hindawi.com/journals/jl/2012/608580/