%0 Journal Article
%T A systematic review and meta
%A Grerk Sutamtewagul
%A Marin L. Schweizer
%A Nattawut Leelakanok
%A Ronilda R. D¡¯Cunha
%J Nutrition and Health
%@ 2047-945X
%D 2018
%R 10.1177/0260106018777170
%X Previous evidence supports that vitamin A decreases the risk of several types of cancer. However, the association between vitamin A and liver cancer is inconclusive. This systematic review and meta-analysis summarizes the existing literature, discussing the association between vitamin A intake, serum vitamin A, and liver cancer in adult populations. A systematic literature review was performed by searching the EMBASE, PubMed, Scopus and International Pharmaceutical Abstract databases using terms related to vitamin A (e.g. retinol, ¦Á-carotene, ¦Â-carotene, and ¦Â-cryptoxanthin) and hepatic cancer without applying any time restriction. A meta-analysis was performed using random effect models. The meta-analysis of five studies showed no association between serum retinol and liver cancer (pooled risk ratio = 1.90 (0.40¨C9.02); n = 5 studies, I2 = 92%). In addition, the systematic review of studies from 1955 to July 2017 found studies that indicated no association between the intake and serum level of ¦Á-carotene (n = 2) and ¦Â-cryptoxanthin (n = 1) and the risk of liver cancer. Further, the associations between retinol intake (n = 3), ¦Â-carotene intake (n = 3), or serum ¦Â-carotene (n = 3) and liver cancer were inconclusive. Current information on the association between vitamin A intake and liver cancer or serum vitamin A and liver cancer are limited. Most studies demonstrated no association between dietary vitamin A and the risk of liver cancer. However, the finding was based on a small number of studies with potential publication bias. Therefore, large observational studies should be conducted to confirm these associations
%K Vitamin a
%K carotenoids
%K beta carotene
%K retinol
%K liver cancer
%K liver neoplasms
%U https://journals.sagepub.com/doi/full/10.1177/0260106018777170