%0 Journal Article
%T A Biosynthetic Numbering System for Diterpene Pyrones
%A Amjad Ayad Qatran Al-Khdhairawi
%A Geoffrey A. Cordell
%A Jean-Fr¨¦d¨¦ric F. Weber
%A Narendra Babu Shivanagere Nagojappa
%J Natural Product Communications
%@ 1555-9475
%D 2019
%R 10.1177/1934578X19860366
%X Diterpene pyrones, spiroditerpenoids, and brevianes are names given to a series of fungal meroterpenoids that share common structural features and a common biosynthetic pathway elaborated by multiple oxidations, rearrangements, and cyclizations to produce the observed structural diversity. A unifying approach to the numbering of these fungal metabolites, based on a common biosynthetic progenitor, a geranylgeranyl-pyrone hybrid, is presented. This proposal will foster simplicity through a standardized numbering system that can be applied to the known members of this family, as well as to future metabolites
%K diterpene pyrones
%K biosynthesis
%K systematic numbering
%K fungal secondary metabolites
%U https://journals.sagepub.com/doi/full/10.1177/1934578X19860366