%0 Journal Article
%T Lamina cribrosa position and Bruch¡¯s membrane opening differences between anterior ischemic optic neuropathy and open
%A Ane P¨¦rez-Sarriegui
%A Francisco J Mu£¿oz-Negrete
%A Gema Rebolleda
%A Laura D¨ªez-¨¢lvarez
%A Victoria De Juan
%J European Journal of Ophthalmology
%@ 1724-6016
%D 2019
%R 10.1177/1120672118782101
%X To compare the optic nerve head morphology among primary open-angle glaucoma, non-arteritic anterior ischemic optic neuropathy eyes, their fellow healthy eyes and control eyes, using spectral-domain optical coherence tomography with enhanced depth imaging. Observational cross-sectional study including 88 eyes of 68 patients. In this study, 23 non-arteritic anterior ischemic optic neuropathy eyes, 17 fellow unaffected eyes, 25 primary open-angle glaucoma eyes, and 23 age-matched control eyes were included. Peripapillary retinal nerve fiber layer thickness and optic disk area were evaluated. Bruch¡¯s membrane opening diameter, optic cup depth, anterior lamina cribrosa depth, and prelaminar tissue thickness were assessed. Non-arteritic anterior ischemic optic neuropathy and primary open-angle glaucoma eyes had similar visual field mean deviation and peripapillary retinal nerve fiber layer thickness (P£¿=£¿0.6 and P£¿=£¿0.56, respectively). Bruch¡¯s membrane opening diameter was significantly larger in primary open-angle glaucoma eyes than in control eyes (P£¿=£¿0.02). Lamina cribrosa and disk cup were deeper in eyes with primary open-angle glaucoma than both control and non-arteritic anterior ischemic optic neuropathy eyes (P£¿<£¿0.001). Prelaminar tissue thickness was significantly thinner in primary open-angle glaucoma eyes than in non-arteritic anterior ischemic optic neuropathy eyes (P£¿<£¿0.001). Lamina cribrosa was shallower in both non-arteritic anterior ischemic optic neuropathy and unaffected fellow eyes compared to healthy eyes (P£¿<£¿0.001 and P£¿=£¿0.04, respectively). No differences were found in the optic disk area. A forward lamina cribrosa placement and not a smaller disk could be involved in the pathogenesis of non-arteritic anterior ischemic optic neuropathy. A significantly larger Bruch¡¯s membrane opening diameter was found in primary open-angle glaucoma eyes compared with control eyes. This issue has clinical implications because Bruch¡¯s membrane opening has been considered a stable reference for disk-related measures
%K Bruch¡¯s membrane opening diameter
%K lamina cribrosa
%K non-arteritic anterior ischemic optic neuropathy
%K optic disk area
%K primary open-angle glaucoma
%U https://journals.sagepub.com/doi/full/10.1177/1120672118782101