%0 Journal Article
%T The RELIEF study: Tolerability and efficacy of preservative
%A Anna Zaleska-Zmijewska
%A Christophe Baudouin
%A Dariusz Rokicki
%A Jaromir Wasyluk
%A Joanna Wierzbowska
%A Karolina Podboraczynska-Jodko
%A Lucyna Mocko
%A Malgorzata Mulak
%A Marek Prost
%A Marek Rekas
%A Maria Pomorska
%A Marta Misiuk-Hojlo
%A Renata Kinasz
%A Renata Ortyl-Markiewicz
%A Wanda Romaniuk
%A Wojciech Lubinski
%J European Journal of Ophthalmology
%@ 1724-6016
%D 2019
%R 10.1177/1120672118785280
%X To assess tolerability and efficacy following a switch from benzalkonium chloride¨Clatanoprost to preservative-free latanoprost in patients with glaucoma or ocular hypertension. A total of 140 patients with glaucoma or ocular hypertension controlled with benzalkonium chloride-latanoprost for at least 3£¿months were switched to treatment with preservative-free latanoprost. Assessments were made on days 15, 45, and 90 (D15, D45, and D90) and included best-corrected visual acuity, intraocular pressure, slit lamp examination, fluorescein staining, tear film break-up time, patient symptom evaluation, and subjective estimation of tolerability. Mean best-corrected visual acuity remained unchanged during the study. Mean intraocular pressure compared with baseline (D0) remained stable throughout the study (D0, 15.9£¿mmHg (standard deviation£¿=£¿2.6); D90, 15.3£¿mmHg (standard deviation£¿=£¿2.4); p£¿<£¿0.006). Tear film break-up time improved or remained unchanged relative to baseline in 92% of patients at D45 and in 93% at D90. Moderate-to-severe conjunctival hyperemia was seen in 56.8% of patients at D0, but this figure decreased to 13.7%, 2.2%, and 1.6% at D15, D45, and D90, respectively. Subjective assessment of tolerability (0¨C10 scale) indicated improvement with change of therapy (mean score: 5.3 (standard deviation£¿=£¿2.2) at D0 versus 1.9 (standard deviation£¿=£¿1.7) at D90; p£¿<£¿0.0001). Preservative-free latanoprost has at least the same intraocular pressure-lowering efficacy as benzalkonium chloride¨Clatanoprost, with a better tolerability profile. This may translate into greater control of treatment and improved quality of life
%K Benzalkonium chloride
%K glaucoma treatment
%K latanoprost
%K preservatives
%K tolerability
%U https://journals.sagepub.com/doi/full/10.1177/1120672118785280