%0 Journal Article
%T Exertional rhabdomyolysis: Relevance of clinical and laboratory findings, and clues for investigation
%A Jan De Bleecker
%A Jonathan Baets
%A Karel Heytens
%A Luc Heytens
%A Willem De Ridder
%J Anaesthesia and Intensive Care
%@ 1448-0271
%D 2019
%R 10.1177/0310057X19835830
%X Some degree of exertional rhabdomyolysis (ER), striated muscle breakdown associated with strenuous exercise, is a well-known phenomenon associated with endurance sports. However in rare cases, severe and/or recurrent ER is a manifestation of an underlying condition, which puts patients at risk for significant morbidity and mortality. Selecting the patients that need a diagnostic work up of an acute rhabdomyolysis episode is an important task. Based on the diagnostic work up of three illustrative patients treated in our hospital, retrospectively using the ¡®RHABDO¡¯ screening tool, we discuss the clinical and biochemical clues that should trigger further investigation for an underlying condition. Finally, we describe the most common genetic causes of this clinical syndrome
%K Exertional rhabdomyolysis
%K creatine kinase
%K myopathies
%K RYR1
%U https://journals.sagepub.com/doi/full/10.1177/0310057X19835830