%0 Journal Article
%T Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report
%A Geert Roozen
%A Hans Kemperman
%A Ingrid Revet
%A Reinier Raymakers
%J Annals of Clinical Biochemistry
%@ 1758-1001
%D 2019
%R 10.1177/0004563218793166
%X The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely high concentrations of plasma ferritin (387,000£¿¦Ìg/L and 138,000£¿¦Ìg/L, respectively) are presented. In both cases, falsely lowered ferritin results were reported without any analyser flag. This article emphasizes the importance of recognition of the high-dose hook effect, since a watertight solution is lacking
%K High-dose hook
%K prozone
%K ferritin
%K haemophagocytic lymphohistiocytosis
%U https://journals.sagepub.com/doi/full/10.1177/0004563218793166