%0 Journal Article
%T Conservative versus conventional oxygen therapy for cardiac surgical patients: A before
%A George Matalanis
%A Glenn M Eastwood
%A Helen Young
%A Hidetoshi Kagaya
%A Johan M£¿rtensson
%A Leah Peck
%A Matthew J Chan
%A Neil J Glassford
%A Rinaldo Bellomo
%A Satoshi Suzuki
%A Sean Galvin
%J Anaesthesia and Intensive Care
%@ 1448-0271
%D 2019
%R 10.1177/0310057X19838753
%X Avoiding hypoxaemia is considered crucial in cardiac surgery patients admitted to the intensive care unit (ICU). However, avoiding hyperoxaemia may also be important. A conservative approach to oxygen therapy may reduce exposure to hyperoxaemia without increasing the risk of hypoxaemia. Using a before-and-after design, we evaluated the introduction of conservative oxygen therapy (target SpO2 88%¨C92% using the lowest FiO2) for cardiac surgical patients admitted to the ICU. We studied 9041 arterial blood gas (ABG) datasets: 4298 ABGs from 245 ¡®conventional¡¯ and 4743 ABGs from 298 ¡®conservative¡¯ oxygen therapy patients. During mechanical ventilation (MV) and while in the ICU, compared to the conventional group, conservative group patients had significantly lower FiO2 exposure and PaO2 values (P£¿<£¿0.001 for each). Accordingly, using the mean PaO2 during MV, more conservative group patients were classified as normoxaemic (226 versus 62 patients, P£¿<£¿0.01), fewer as hyperoxaemic (66 versus 178 patients, P£¿<£¿0.01) and no patient in either group as hypoxaemic or severely hypoxaemic. Moreover, more ABG samples were hyperoxaemic or severely hyperoxaemic during conventional treatment (P£¿<£¿0.001). Finally, there was no difference in ICU or hospital length of stay, ICU or hospital mortality or 30-day mortality between the groups. Our findings support the feasibility and physiological safety of conservative oxygen therapy in patients admitted to ICU after cardiac surgery
%K Cardiac surgery
%K oxygen therapy
%K mechanical ventilation
%K intensive care
%U https://journals.sagepub.com/doi/full/10.1177/0310057X19838753