%0 Journal Article
%T Effects of collagen/¦Â
%A Ali Karami
%A Hamid Tebyanian
%A Hossein Eyni
%A Mansoureh Movahedin
%A Mohammad Hadi Norahan
%A Mohammad Reza Nourani
%A Nafiseh Baheiraei
%A SM Javad Mortazavi
%J Journal of Applied Biomaterials & Functional Materials
%@ 2280-8000
%D 2019
%R 10.1177/2280800018820490
%X Bone defects remain a significant health issue and a major cause of morbidity in elderly patients. Composites based on collagen/calcium phosphate have been widely used for bone repair in clinical applications, owing to their comparability to bone extracellular matrix. This study aimed to evaluate the effects of a scaffold of collagen/calcium phosphate (COL/¦Â-TCP) on bone formation to assess its potential use as a bone substitute to repair bone defects. Bilateral full-thickness critically sized calvarial defects (8 mm in diameter) were created in New Zealand white rabbits and treated with COL/¦Â-TCP or COL scaffolds. One defect was also left unfilled as a control. Bone regeneration was assessed through histological evaluation using hematoxylin and eosin and Masson¡¯s trichrome staining after 4 and 8 weeks. Alizarin Red staining was also utilized to observe the mineralization process. Our findings indicated that COL/¦Â-TCP implantation could better enhance bone regeneration than COL and exhibited both new bone growth and scaffold material degradation
%K ¦Â-tricalcium phosphate
%K collagen
%K bone substitute
%U https://journals.sagepub.com/doi/full/10.1177/2280800018820490