%0 Journal Article
%T Clinical Presentation and Outcome in Autoimmune Encephalitis Associated With N
%A Eric Segal
%A Firas Taha
%A Jeffrey Kornitzer
%J Journal of Child Neurology
%@ 1708-8283
%D 2019
%R 10.1177/0883073819840448
%X We present the diagnostic and clinical course of the first multicenter case series of pediatric patients with autoimmune encephalitis associated with N-type voltage-gated calcium channel antibodies. Data from 2 university hospitals were retrospectively reviewed and records of 3 patients with autoimmune encephalitis associated with N-type voltage-gated calcium channel antibodies were evaluated. The 3 pediatric patients (all female) had symptoms that spanned the clinical spectrum. All 3, however, had regression of expressive language and agitation. Neuroimaging in all 3 patients was normal; electroencephalographic (EEG) findings varied among the 3 patients. Positive titers against the N-type voltage-gated calcium channel antibody were found in their cerebrospinal fluid. Following administration of intravenous immunoglobulin, all 3 had improvement in their core presenting symptoms. Autoimmune encephalitis associated with N-type voltage-gated calcium channel antibodies in the pediatric population presents with a wide clinical spectrum, although expressive language delay and agitation seem to be common symptoms. Treatment with intravenous immunoglobulin improves core symptoms
%K autoimmune diseases
%K encephalitis
%U https://journals.sagepub.com/doi/full/10.1177/0883073819840448