%0 Journal Article %T Health %A Kerrie-Anne Frakes %A Petrea Cornwell %A Steven McPhail %A Suzanne Kuys %A Zephanie Tyack %J Chronic Illness %@ 1745-9206 %D 2018 %R 10.1177/1742395317724849 %X This study examined the relationship between the number of comorbidities and health-related quality of life (HRQoL) and between select physical conditions and HRQoL. Differences in HRQoL in comparison to a normative sample were also examined. A cross-sectional study among people with multimorbidity (n = 401) attending a community-based, interdisciplinary health clinic was conducted. HRQoL was measured using the eight dimensions of the SF-36. Multiple linear regression and t-tests were used to analyse the data. A downward trend in HRQoL continued from 2 to 14 concurrent comorbidities. Patients with a higher number of comorbidities reported greater deficits in HRQoL, when age, gender, education and perceived social support were controlled for (beta = £¿0.11 to £¿0.31). The impact of the number of comorbidities was greatest for the bodily pain dimension of the SF-36 (beta = £¿0.31). Deficits were greatest for people with gastrointestinal conditions and back pain or sciatica. Moderate to large deficits in HRQoL compared to a normative population were found (Cohen¡¯s d = 0.54¨C1.16). Understanding associations between the number and type of physical comorbidities and HRQoL may assist clinical services to design broad but targeted interventions to optimize HRQoL in this group of people %K Health-related quality of life %K chronic disease %K multimorbidity %K multimorbidity epidemiology %K complex chronic conditions %U https://journals.sagepub.com/doi/full/10.1177/1742395317724849