%0 Journal Article
%T The importance of hCG in human endometrial adenocarcinoma and breast cancer
%A Alexandra C. K£¿lbl
%A Kristina Schlenk
%A Nils Behrendt
%A Ulrich Andergassen
%J The International Journal of Biological Markers
%@ 1724-6008
%D 2018
%R 10.5301/ijbm.5000290
%X Human chorionic gonadotropin (hCG) is a peptide hormone which plays an important role during pregnancy. But its impact is not limited to pregnancy; it also influences tumor formation and metastatic outgrowth, especially in endometrial adenocarcinoma and breast cancer. This review summarizes what has been written in the literature about the role of hCG as a tumor marker in these 2 gynecological malignancies and also about the signal transduction pathways in which hCG is involved. HCG can, on the one hand, be a marker for the progression of a malignant disease, and on the other hand, it may be a point for therapeutical intervention, so further research into this molecule would be very much worthwhile
%K Breast cancer
%K Endometrial adenocarcinoma
%K hCG
%K Therapy
%K Tumor marker
%U https://journals.sagepub.com/doi/full/10.5301/ijbm.5000290