%0 Journal Article
%T Sleep
%A A.R.G. Cortes
%A C. Flores-Mir
%A D. Gozal
%A D. Graf
%A H. Eimar
%A M.A.Q. Al-Saleh
%J JDR Clinical & Translational Research
%@ 2380-0852
%D 2019
%R 10.1177/2380084418776906
%X Evidence from the adult population suggests that sleep-disordered breathing (SDB) (i.e., obstructive sleep apnea [OSA]) is negatively associated with bone mineral density. Whether a similar association exists in children with SDB has not been investigated. Using the mandibular cortical width (MCW) as a proxy for skeletal bone density, we investigated if children at risk of SDB or diagnosed with OSA have a reduced mandibular cortical width compared to children without SDB. Two retrospective cross-sectional studies were performed. The first study included comparison of MCW between 24 children with polysomnographically (PSG) diagnosed OSA and 72 age- and sex-matched control children. The second study included a cohort of children in which SDB was suggested by the Pediatric Sleep Questionnaire (PSQ) (n = 101). MCW was measured from panoramic radiographs. Multiple-predictors regression analysis from the first study indicated that in children with a severe form of SDB, as induced by OSA severity, there was a negative association with MCW (¦Â = ¨C0.290, P = 0.049). Moreover, PSG-diagnosed OSA children had thinner MCW (2.9. ¡À 0.6mm) compared to healthy children (3.5 ¡À 0.6 mm; P = 0.002). These findings were further supported by the second study illustrating that PSQ total scores were negatively associated with MCW (¦Â = ¨C0.391, P < 0.001). Findings suggest that children at risk for or diagnosed with SDB exhibit reduced mandibular cortical width that purportedly may reflect alterations in bone homeostasis. We report that sleep-disordered breathing (including its severe form, obstructive sleep apnea) in children is associated with reduced mandibular cortical width. This association might be a direct consequence of reduced bone health to sleep-disordered breathing or a reflection that reduced bone formation underlies the development of sleep-disordered breathing. Our findings suggest that mandibular cortical width can be used as an adjunct diagnostic parameter for the diagnosis of sleep-disordered breathing
%K sleep apnea syndromes
%K mandible
%K cortical bone
%K dental
%K cone-beam computed tomography
%K child
%U https://journals.sagepub.com/doi/full/10.1177/2380084418776906