%0 Journal Article
%T Efficacy and Limitations of rCBF
%A Keitaro Koyama
%A Miwako Takahashi
%A Tomoko Tada
%A Tomomi Nakamura
%A Toshimitsu Momose
%J American Journal of Alzheimer's Disease & Other Dementias£¿
%@ 1938-2731
%D 2019
%R 10.1177/1533317519841192
%X This study aimed to assess efficacy and limitations of regional cerebral blood flow imaging using single-photon emission computed tomography (rCBF-SPECT) in the diagnosis of Alzheimer¡¯s disease (AD) with amyloid-positron emission tomography (amyloid-PET). Thirteen patients, who underwent both rCBF-SPECT and amyloid-PET after clinical diagnosis of AD or mild cognitive impairment, were retrospectively identified. The rCBF-SPECTs were classified into 4 grades, from typical AD pattern to no AD pattern of hypoperfusion; amyloid-beta (A¦Â) positivity was assessed by amyloid-PET. Four patients were categorized into a typical AD pattern on rCBF-SPECT, and all were A¦Â+. The other 9 patients did not exhibit a typical AD pattern; however, 4 were A¦Â+. The Mini-Mental State Examination score and Clinical Dementia Rating scale were not significantly different between A¦Â+ and A¦Â¨C patients. A typical AD pattern on rCBF-SPECT can reflect A¦Â+; however, if not, rCBF-SPECT has a limitation to predict amyloid pathology
%K regional cerebral blood flow SPECT
%K amyloid-PET
%K Alzheimer¡¯s disease
%K mild cognitive impairment
%K florbetapir-PET
%U https://journals.sagepub.com/doi/full/10.1177/1533317519841192