%0 Journal Article
%T Platelet Membrane ¦£
%A Aylin Yildirir
%A Ay£¿eg¨¹l Haberal
%A Ibrahim Haldun M¨¹derriso£¿lu
%A Koray Demirta£¿
%A Leyla Elif Sade
%A Mehmet B¨¹lent £¿zin
%A £¿a£¿ri Yayla
%J Angiology
%@ 1940-1574
%D 2019
%R 10.1177/0003319718787367
%X ¦Ã-Glutamyl transferase (GGT) participates in oxidative and inflammatory reactions inside the atheroma plaque and platelets. We evaluated whether platelet membrane ¦Ã-glutamyl transferase (Plt-GGT) activity is a predictor of major adverse cardiac events (MACEs) during 3 months follow-up of patients with acute coronary syndrome (ACS; MACE-3M). We included 105 patients who were hospitalized consecutively with the diagnosis of ACS. Patients with an MACE-3M were older, more likely to have hypertension, hyperlipidemia, family history of coronary artery disease(CAD), thrombolysis in myocardial infarction (TIMI) risk score >4, higher Plt-GGT and serum GGT activities, serum C-reactive protein level, and lower left ventricular ejection fraction (LVEF) when compared to those without MACE-3M (all P values ¡Ü.05). By receiver¨Coperator characteristic (ROC) curve analysis, 265 mU/mg for Plt-GGT, 30 U/L for serum GGT, and 45% for LVEF were determined as cutoff values to discriminate MACEs. Platelet GGT activity >265 mU/mg, TIMI risk score >4, and family history of CAD were independent predictors of MACE-3M (all P values <.05). Platelet GGT activity was as an independent predictor for MACEs in patients with ACS during the 3 months follow-up
%K acute coronary syndrome
%K MACE
%K platelet
%K ¦Ã-glutamyl transferase
%U https://journals.sagepub.com/doi/full/10.1177/0003319718787367