%0 Journal Article
%T Sinus of Valsalva Aneurysm and Infective Endocarditis Involving a Bicuspid Aortic Valve in an Infant With Trisomy 21
%A Michael Chambliss
%A Nicole A. Croom
%A Nicole Therrien
%A Philip C. Ursell
%J Academic Forensic Pathology
%@ 1925-3621
%D 2018
%R 10.1177/1925362118797753
%X A 19-month-old girl with trisomy 21 and a congenitally bicuspid aortic valve died following a short febrile illness. Autopsy disclosed pericarditis, epimyocardial abscess, infective endocarditis, and a sinus of Valsalva aneurysm. Microscopy demonstrated continuity between the aortic wall and valve leaflet, consistent with an acquired aneurysm. Abnormal hemodynamics associated with the valve malformation likely facilitated endocarditis
%K Forensic pathology
%K Sinus of Valsalva aneurysm
%K Bicuspid aortic valve
%K Infective endocarditis
%K Congenital heart defect
%K Trisomy 21
%U https://journals.sagepub.com/doi/full/10.1177/1925362118797753