%0 Journal Article %T Ambiguity, death determination, and the dead donor rule %A Will Lyon %J Clinical Ethics %@ 1758-101X %D 2018 %R 10.1177/1477750918790021 %X The dead donor rule states that organ donors must be declared dead before any vital organs are removed. Recently, scholars and physicians have argued for the abandonment of the dead donor rule, based on the rule¡¯s supposed connection with the concept of brain death, which they view as a conceptually unreliable definition of death. In this essay, I distinguish between methods of death determination and the question of whether or not the dead donor rule should be a guiding principle of organ transplant ethics. In principle, the dead donor rule does not rely on any one definition of death, but only prohibits the taking of vital organs before a patient is declared dead. In light of this distinction, I argue that even if the dead donor rule is tied to brain death in practice, conceptual disagreement about brain death does not provide grounds for rejection of this rule. I then present evidence in support of the consistency and reliability of the diagnosis of brain death. I show that, when performed carefully and under specific clinical circumstances, the diagnosis of brain death is considered by most neurologists to be reliable. Finally, I argue that, without the dead donor rule, organ transplantation programs would become susceptible to violations of the ethical principle of respect for persons %K Assisted suicide %K clinical ethics %K determination of death %K death and dying %K euthanasia and allowing to die %K donation and procurement %K organ and tissue transplantation %K legal aspects %U https://journals.sagepub.com/doi/full/10.1177/1477750918790021