%0 Journal Article
%T ¦Â
%A Diego A Herrera
%A Jorge Montoya
%A Juliana Jimenez
%A Mauricio Castillo
%A Sergio A Vargas
%J The Neuroradiology Journal
%@ 2385-1996
%D 2019
%R 10.1177/1971400919828142
%X Patients with mutations in tubulin-related genes usually present with brain malformations, intellectual disability, epilepsy, microcephaly and ocular abnormalities. In these patients the diagnosis can be suggested by neuroimaging findings. We report a 5-year-old patient with characteristic magnetic resonance imaging findings including malformation of cortical development, fused basal ganglia, large head of the caudate nuclei, absent anterior limbs of the internal capsules, corpus callosum dysgenesis and dysplastic cerebellar vermis. Sequencing of the TUBB2B gene confirmed a heterozygous mutation: c. 260C>A (p. Pro87Gln)
%K Microtubules
%K tubulin
%K brain malformations
%K epilepsy
%K TUBB2B
%K neurodevelopmental delays
%U https://journals.sagepub.com/doi/full/10.1177/1971400919828142