%0 Journal Article
%T BMP Signaling in Regulating Mesenchymal Stem Cells in Incisor Homeostasis
%A C. Shi
%A J. Feng
%A J. Jing
%A J. Li
%A T.V. Ho
%A X. Han
%A Y. Chai
%A Y. Guo
%A Y. Yuan
%J Journal of Dental Research
%@ 1544-0591
%D 2019
%R 10.1177/0022034519850812
%X Bone morphogenetic protein (BMP) signaling performs multiple essential functions during craniofacial development. In this study, we used the adult mouse incisor as a model to uncover how BMP signaling maintains tissue homeostasis and regulates mesenchymal stem cell (MSC) fate by mediating WNT and FGF signaling. We observed a severe defect in the proximal region of the adult mouse incisor after loss of BMP signaling in the Gli1+ cell lineage, indicating that BMP signaling is required for cell proliferation and odontoblast differentiation. Our study demonstrates that BMP signaling serves as a key regulator that antagonizes WNT and FGF signaling to regulate MSC lineage commitment. In addition, BMP signaling in the Gli1+ cell lineage is also required for the maintenance of quiescent MSCs, suggesting that BMP signaling not only is important for odontoblast differentiation but also plays a crucial role in providing feedback to the MSC population. This study highlights multiple important roles of BMP signaling in regulating tissue homeostasis
%K cell proliferation
%K differentiation
%K stem cells
%K tooth
%K odontoblast
%K growth factor signaling
%U https://journals.sagepub.com/doi/full/10.1177/0022034519850812