%0 Journal Article
%T Exploring the Impact of Adding a Respiratory Dimension to the EQ
%A Elly A. Stolk
%A Lucas M. A. Goossens
%A Mark Oppe
%A Martine Hoogendoorn
%A Maureen P. M. H. Rutten每van Mˋlken
%A Melinde R. S. Boland
%J Medical Decision Making
%@ 1552-681X
%D 2019
%R 10.1177/0272989X19847983
%X Objectives. To evaluate the impact of adding a respiratory dimension (a bolt-on dimension) to the EQ-5D-5L health state valuations. Methods. Based on extensive regression and principal component analyses, 2 respiratory bolt-on candidates were formulated: R1, limitations in physical activities due to shortness of breath, and R2, breathing problems. Valuation interviews for the selected bolt-ons were performed with a representative sample from the Dutch general public using the standardized interview protocol and software of the EuroQol group. Hybrid models based on the combined time-tradeoff (TTO) and discrete choice experiment (DCE) data were estimated to assess whether the 5 levels of the respiratory bolt-on led to significant changes in utility values. Results. For each bolt-on candidate, slightly more than 200 valuation interviews were conducted. Mean TTO values and DCE choice probabilities for health states with a level 4 or 5 for the respiratory dimension were significantly lower compared with the same health states in the Dutch EQ-5D-5L valuation study without the respiratory dimension. Results of hybrid models showed that for the bolt-on ※limitations in physical activities,§ the utility decrements were significant for level 3 (每0.055), level 4 (每0.087), and level 5 (每0.135). For ※breathing problems,§ the utility decrements for the same levels were greater (每0.086, 每0.219, and 每0.327, respectively). Conclusions. The addition of each of the 2 respiratory bolt-ons to the EQ-5D-5L had a significant effect on the valuation of health states with severe levels for the bolt-on. The bolt-on dimension ※breathing problems§ showed the greatest utility decrements and therefore seems the most appropriate respiratory bolt-on dimension
%K EQ-5D
%K respiratory symptoms
%K bolt-on
%K valuation study
%K pilot
%U https://journals.sagepub.com/doi/full/10.1177/0272989X19847983