%0 Journal Article
%T A rare case of crystalglobulinemia
%A Bhanu Prasad
%A Rajni Chibbar
%A Salim Muhammad
%A Sanjeev Sethi
%J Journal of Onco
%@ 2399-3707
%D 2019
%R 10.1177/2399369318824975
%X Crystalglobulinemia is an extremely rare complication of monoclonal gammopathy. We report a 49-year-old female who presented with acute kidney injury, microhematuria, and non-nephrotic range proteinuria. Eight weeks prior to presentation, she developed a lower urinary tract infection and acute kidney injury, but her creatinine failed to resolve after resolution of her symptoms with antibiotics. Kidney biopsy revealed a membranoproliferative pattern of injury, and numerous crystals were noted in the glomerular capillaries on electron microscopy. On immunofluorescence, positive staining for immunoglobulin G and kappa was demonstrated in the capillary lumen along the capillary walls. Based on the biopsy, a diagnosis of crystalglobulinemia was made. On serum protein electrophoresis, there was presence of a monoclonal band, which was too small to quantify. Urine immunofixation was negative. Patient was treated with cyclophosphamide, bortezomib, and dexamethasone regime and made a remarkable renal recovery
%K Crystal glomerulopathy (GN)
%K monoclonal gammopathy of undetermined significance
%K monoclonal gammopathy of renal significance
%U https://journals.sagepub.com/doi/full/10.1177/2399369318824975