%0 Journal Article
%T Retrospective Cohort Study: Ledipasvir
%A Ives Hot
%A Kelsey L. Hawkins
%J Journal of Pharmacy Technology
%@ 1549-4810
%D 2018
%R 10.1177/8755122518782478
%X Background: Liver damage caused by hepatitis C virus (HCV) is the number one indication for liver transplantation in the United States and Europe. Patients with a detectable HCV level at time of transplant will universally develop a recurrent infection, which can lead to increased morbidity and mortality. Objective: To assess the sustained virologic response rate post end-of-treatment (SVR) in HCV-infected, post¨Cliver transplant patients at the University of Washington Medical Center (UWMC) treated with ledipasvir-sofosbuvir (LDV/SOF). Methods: This retrospective, cohort study of HCV-positive, genotype 1 or 4 infected, post¨Cliver transplant patients treated with LDV/SOF was conducted at a large academic medical center affiliated clinic. Patients treated with 12 weeks of LDV/SOF with or without ribavirin were included in the 12-week group, and patients treated with 24 weeks of LDV/SOF without ribavirin were included in the 24-week group. Results: Twenty-nine patients with recurrent HCV post¨Cliver transplant receiving 12 weeks of LDV/SOF with or without ribavirin and 32 patients receiving 24 weeks of LDV/SOF alone were assessed. SVR was achieved by 100% (29/29) of patients in the 12-week group and 100% (32/32) of patients in the 24-week group. Conclusion: Post¨Cliver transplant patients at UWMC treated with LDV/SOF for recurrent HCV achieved high rates of SVR
%K hepatitis C
%K ambulatory care
%K antivirals
%K transplants
%K clinical pharmacy
%U https://journals.sagepub.com/doi/full/10.1177/8755122518782478