%0 Journal Article
%T Accuracy of diffusion
%A Abdorrahim Absalan
%A Afshin Moradi
%A Anahita Fathi Kazerooni
%A Farnaz Kimia
%A Hamidreza Haghighatkhah
%A Hamidreza Saligheh Rad
%A Mersad Mehrnahad
%A Mohammadreza Alviri
%A Morteza Sanei Taheri
%J The Neuroradiology Journal
%@ 2385-1996
%D 2019
%R 10.1177/1971400918809825
%X The purpose of this study was to determine the accuracy of selected first or second-order histogram features in differentiation of functional types of pituitary macro-adenomas. Diffusion-weighted imaging magnetic resonance imaging was performed on 32 patients (age mean㊣standard deviationˋ=ˋ43.09ˋ㊣ˋ11.02 years; minˋ=ˋ22 and maxˋ=ˋ65 years) with pituitary macro-adenoma (10 with functional and 22 with non-functional tumors). Histograms of apparent diffusion coefficient were generated from regions of interest and selected first or second-order histogram features were extracted. Collagen contents of the surgically resected tumors were examined histochemically using Masson trichromatic staining and graded as containing <1%, 1每3%, and >3% of collagen. Among selected first or second-order histogram features, uniformity (pˋ=ˋ0.02), 75th percentile (pˋ=ˋ0.03), and tumor smoothness (pˋ=ˋ0.02) were significantly different between functional and non-functional tumors. Tumor smoothnessˋ>ˋ5.7ˋ℅ˋ10ˋ9 (area under the curveˋ=ˋ0.75; 0.56每0.89) had 70% (95% confidence intervalˋ=ˋ34.8每93.3%) sensitivity and 33.33% (95% confidence intervalˋ=ˋ14.6每57.0%) specificity for diagnosis of functional tumors. Uniformity ≒179.271 had a sensitivity of 60% (95% confidence intervalˋ=ˋ26.2每87.8%) and specificity of 90.48% (95% confidence intervalˋ=ˋ69.6每98.8%) with area under the curveˋ=ˋ0.76; 0.57每0.89. The 75th percentile >0.7 had a sensitivity of 80% (95% confidence intervalˋ=ˋ44.4每97.5%) and specificity of 66.67% (95% confidence intervalˋ=ˋ43.0每85.4%) for categorizing tumors to functional and non-functional types (area under the curveˋ=ˋ0.74; 0.55每0.88). Using these cut-offs, smoothness and uniformity are suggested as negative predictive indices (non-functional tumors) whereas 75th percentile is more applicable for diagnosis of functional tumors. First or second-order histogram features could be helpful in differentiating functional vs non-functional pituitary macro-adenoma tumors
%K Pituitary adenoma
%K tumor consistency
%K apparent diffusion coefficient
%K magnetic resonance imaging
%U https://journals.sagepub.com/doi/full/10.1177/1971400918809825