%0 Journal Article
%T 3,3’-双(哌啶-1-甲基)八氢联萘酚的合成<br>Synthesis of (S)-3,3’-Bis(Piperidin-1-Ylmethyl)-H8BINOL
%A 汤佳凡
%A 毛明明
%A 符世玮
%J Studies in Synthetic Chemistry
%P 43-47
%@ 2332-7960
%D 2020
%I Hans Publishing
%R 10.12677/SSC.2020.82005
%X 开发了一种通过类曼尼希反应制备3,3’-双(哌啶-1-甲基)八氢联萘酚简捷的一锅法合成方法。在溶剂甲醇中，使用廉价易得的哌啶盐酸盐替代管制品哌啶，以高达81.1%的收率得到3,3’-双(哌啶-1-甲基)八氢联萘酚。该法不仅反应条件温和，后处理操作简单，而且收率高。<br />
A concise one-pot synthetic method was developed to prepare (S)-3,3’-bis(piperidin-1-ylmethyl)- octahydrobinaphthol (H8BINOL) by Mannich-type reaction. In the solvent methanol, (S)-3,3’-bis (piperidin-1-ylmethyl) octahydrobinaphthol was obtained in high yield of up to 81.1% using cheap and readily available piperidine hydrochloride to replace the controlled chemical piperidine.
%K 合成，类曼尼希反应，八氢联萘酚<br>Synthesis
%K Mannich-Type Reaction
%K H8BINOL
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=35541