%0 Journal Article
%T Association of Race and Change in Ankle-Brachial Index: The Atherosclerosis Risk in Communities (ARIC) Cohort
%A Ericha Franey
%A Donna Kritz-Silverstein
%A Erin Richard
%A John Alcaraz
%A Caroline Nievergelt
%A Richard Shaffer
%A Vibha Bhatnagar
%J Advances in Aging Research
%P 77-93
%@ 2169-0502
%D 2020
%I Scientific Research Publishing
%R 10.4236/aar.2020.95007
%X <strong>Objective</strong>: <span><span><span style=\"font-family:verdana;\">This study evaluates the association of self-reported race with</span><span style=\"font-family:'Minion Pro Capt','serif';\"><span style=\"font-family:Verdana;\"> change in ankle-brachial index (ABI) over time and modification of this association by paraoxonase gene (</span><i><span style=\"font-family:Verdana;\">PON</span></i><span style=\"font-family:Verdana;\">1,</span><i><span style=\"font-family:Verdana;\"> PON</span></i><span style=\"font-family:Verdana;\">2</span><i><span style=\"font-family:Verdana;\"> and PON</span></i><span style=\"font-family:Verdana;\">3) single nucleotide polymorphisms (SNPs). </span></span><b><span style=\"font-family:verdana;\">Methods: </span></b></span></span><span style=\"font-family:verdana;\"><span style=\"font-family:verdana;\"><span style=\"font-family:verdana;\"><span style=\"font-family:verdana;\">This longitudinal study included 11,992 (N</span></span></span></span><span><span><span><span style=\"font-family:'Minion Pro Capt','serif';\"> </span><span style=\"font-family:verdana;\">=</span><span style=\"font-family:'Minion Pro Capt','serif';\"> </span><span style=\"font-family:verdana;\">2952 Black,</span><span style=\"font-family:'Minion Pro Capt','serif';\"> </span><span style=\"font-family:verdana;\">N</span><span style=\"font-family:'Minion Pro Capt','serif';\"> </span><span style=\"font-family:verdana;\">=</span><span style=\"font-family:'Minion Pro Capt','serif';\"> </span><span style=\"font-family:'Minion Pro Capt','serif';\"><span style=\"font-family:Verdana;\">9040 White) participants from the Atherosclerosis Risk in Com</span><span style=\"font-family:verdana;\">munities (ARIC) cohort with PON genotyping. Mixed-effects models ex</span><span style=\"font-family:Verdana;\">amined whether race was associated with change in ABI over time after adjustment for known peripheral artery disease (PAD) risk factors.</span></span></span></span></span><span><span><span><span style=\"font-family:'Minion Pro Capt','serif';\"> </span><b><span style=\"font-family:verdana;\">Results:</span></b><i><span style=\"font-family:'Minion Pro Capt','serif';\"> </span></i><span style=\"font-family:verdana;\">Change in ABI over time differed between Whites and Blacks (race-time interaction,</span><span style=\"font-family:'Minion Pro Capt','serif';\"> </span><span style=\"font-family:verdana;\">p</span><span style=\"font-family:'Minion Pro Capt','serif';\"> </span><span style=\"font-family:verdana;\">&lt;</span><span style=\"font-family:'Minion Pro
%K ankle-brachial index
%K ARIC
%K paraoxonase
%K PAD
%K peripheral artery disease
%K SNP
%K single nucleotide polymorphism
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=103279