%0 Journal Article
%T Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
%A Boers
%A Frank
%A Clauss
%A Ralf
%A Dammers
%A Ju£¿rgen
%A Filss
%A Christian P.
%A Galldiks
%A Norbert
%A Langen
%A Karl-Josef
%A Rosenberg
%A Jessica
%A Shah
%A N. Jon
%A Sripad
%A Praveen
%J -
%D 2020
%R https://doi.org/10.1155/2020/8597062
%X In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson¡¯s disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4¨C12£¿Hz) and lower beta (15¨C20£¿Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20¨C43£¿Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI
%U https://www.hindawi.com/journals/crinm/2020/8597062/