%0 Journal Article
%T 5-2-1 Criteria: A Simple Screening Tool for Identifying Advanced PD Patients Who Need an Optimization of Parkinson¡¯s Treatment
%A Aneiros D¨ªaz
%A A.
%A McAfee
%A D.
%A Santos-Garc¨ªa
%A D.
%A Su¨¢rez Castro
%A E.
%A de Deus Fonticoba
%A T.
%J -
%D 2020
%R https://doi.org/10.1155/2020/7537924
%X Objective. 5- (5 times oral levodopa tablet taken/day) 2- (2 hours of OFF time/day) 1- (1 hour/day of troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson¡¯s disease (PD). The aim of the present study is to compare quality of life (QoL) in PD patients with ¡°5-2-1 positive criteria¡± vs QoL in PD patients without ¡°5-2-1 positive criteria¡± (defined as meeting ¡Ý1 of the criteria). Methods. This is a cross-sectional, observational, monocenter study. Three different instruments were used to assess QoL: the 39-Item Parkinson¡¯s Disease Quality of Life Questionnaire Summary Index Score (PDQ-39SI); a subjective rating of perceived QoL (PQ-10); and the EUROHIS-QOL 8-Item Index (EUROHIS-QOL8). Results. From a cohort of 102 PD patients (65.4£¿¡À£¿8.2 years old, 53.9% males; disease duration 4.7£¿¡À£¿4.5 years), 20 (19.6%) presented positive 5-2-1 criteria: 6.9% for 5, 17.6% for 2, and 4.9% for 1. 37.5% (12/32) and 25% (5/20) of patients with motor complications and dyskinesia, respectively, presented 5-2-1 negative criteria. Both health-related (PDQ-39SI, 25.6£¿¡À£¿14 vs 12.1£¿¡À£¿9.2; ) and global QoL (PQ-10, 6.1£¿¡À£¿2 vs 7.1£¿¡À£¿1.3; ; EUROHIS-QOL8, 3.5£¿¡À£¿0.5 vs 3.7£¿¡À£¿0.4; ) were worse in patients with 5-2-1 positive criteria. Moreover, nonmotor symptoms burden (Non-Motor Symptoms Scale total score, 64.8£¿¡À£¿44.8 vs 39.4£¿¡À£¿35.1; ) and autonomy for activities of daily living (ADLS scale, 73.5£¿¡À£¿13.1 vs 89.2£¿¡À£¿9.3; ) were worse in patients with 5-2-1 positive criteria. Patient¡¯s principal caregiver¡¯s strain (Caregiver Stain Index, 4.3£¿¡À£¿3 vs 1.5£¿¡À£¿1.6; ), burden (Zarit Caregiver Burden Inventory, 28.4£¿¡À£¿12.5 vs 10.9£¿¡À£¿9.8; ), and mood (Beck Depression Inventory II, 12.2£¿¡À£¿7.2 vs 6.2£¿¡À£¿6.1; ) were worse in patients with 5-2-1 positive criteria as well. Conclusions. QoL is worse in patients meeting ¡Ý1 of the 5-2-1 criteria. This group of patients and their caregivers are more affected as a whole. These criteria could be useful for identifying patients in which it is necessary to optimize Parkinson¡¯s treatment
%U https://www.hindawi.com/journals/pd/2020/7537924/