%0 Journal Article
%T Impact of Treatment with Direct Acting Antiviral Drugs on Glycemic Control in Patients with Hepatitis C and Diabetes Mellitus
%A Adley
%A Sharon
%A Alam
%A Mohammed J.
%A Castano
%A Gabriel
%A Chen
%A Bing
%A Feldman
%A Mark
%A Hieda
%A Michinari
%A King
%A John William
%A Mada
%A Pradeep Kumar
%A Malus
%A Matthew E.
%A Moore
%A Maureen
%A Parvathaneni
%A Arvin
%J -
%D 2020
%R https://doi.org/10.1155/2020/6438753
%X Aim. To assess the effect of treating chronic hepatitis C virus (HCV) infection with direct acting antiviral drugs (DAAs) on glycemic control in patients with concomitant diabetes mellitus (DM). Methods. We performed a retrospective case-control study in a viral hepatitis ambulatory clinic in Shreveport, Louisiana, during the period 11/01/2014 to 12/31/2017. All the clinic patient ages 18 years and above with treatment-na£żve/biopsy-proven chronic hepatitis C and DM ( ) who were eligible for treatment were included in the study. Of 118 such patients, 59 were treated with oral DAAs for 8-12 weeks with the goal of achieving a sustained virologic response (SVR). A control group of 59 patients did not receive treatment for their hepatitis C and was followed in the clinic. Patients in the control group did not receive treatment either due to insurance issues or refusal of hepatitis C treatment. Results. Fifty-five of the 59 patients treated with DAAs (93%) achieved a SVR. Six months after treatment completion, their HbA1C level had decreased by ( ). Four of the 59 patients treated with DAAs did not achieve a SVR. Their mean HbA1C 6 months after treatment completion had increased by . Furthermore, there was no improvement in HbA1C levels over time in the untreated group (mean HbA1C increase, ; vs. the treatment group, which had a mean HbA1C decrease of ). Conclusion. This controlled study demonstrated that treatment of chronic hepatitis C with DAAs results in statistically significant and meaningful reductions in hemoglobin A1C levels in patients with coexisting diabetic mellitus if a SVR is achieved
%U https://www.hindawi.com/journals/ijh/2020/6438753/