%0 Journal Article
%T Regulation of Hematopoietic Activity  Involving New Interacting Partners  (RRAGC & PSMC2, CKAP4 & MANF and  CTR9 & CNTNAP2)
%A Swati Sharma
%A Gurudutta U. Gangenahalli
%A Upma Singh
%J CellBio
%P 123-141
%@ 2325-7792
%D 2020
%I Scientific Research Publishing
%R 10.4236/cellbio.2020.93007
%X Hematopoietic stem cells (HSCs) are tissue-specific cells giving rise to all mature blood cell types regulated by a diverse group of hematopoietic cytokines and growth factors that influences the survival & proliferation of early progenitors and differentiation mechanisms by modulating the functional activities of HSCs. In this study, the functional yet distinctive role of three novel combinations of gene pairs RRAGC & PSMC2; CKAP4 & MANF; and CTR9 & CNTNAP2 have been newly identified. These novel combinations of genes were confirmed and expressed in K562 human leukemic cell line in the presence of cytokine combination (IL-3, FLT-3 and SCF) using RT-PCR and siRNA-mediated gene knock down strategy. This study signifies the synergistic role of gene pairs in different molecular activities like ubiquitination or proteasomal degradation, calcium mobilization, dopamine signaling.
%K Hematopoietic Stem Cells (HSCs)
%K Signal Transduction
%K Haematopoiesis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=104645