%0 Journal Article
%T Myocardial Protection with Beta Blocker Treatment in Infants with Heart  Failure Due to Congenital Heart  Defects and Duchenne  Muscular Dystrophy
%A Buchhorn Reiner
%J Open Journal of Thoracic Surgery
%P 81-88
%@ 2164-3067
%D 2020
%I Scientific Research Publishing
%R 10.4236/ojts.2020.104008
%X Our first intention to treat infantsĄ¯ heart failure with beta blockers was to improve the clinical condition as shown in our prospective randomized trial. We only use non-selective beta blockers in these infants, carvedilol in those with left ventricular dysfunction and propranolol in those with congenital heart disease without ventricular dysfunction. Despite a significant improvement of RossĄ¯s heart failure score, we could not convince most colleagues within the last 25 years if the concept of neurohumoral activation in heart failure is not well-established pediatric cardiology. Recently, Honghai Liu et al. published that cardiomyocyte cytokinesis failure was increased in congenital heart disease. Inactivation of the beta adreno receptors genes and administration of the beta-blocker propranolol increased cardiomyocyte division in neonatal mice, which increased the number of cardiomyocytes (endowment) and conferred benefit after myocardial infarction in adults. We currently realize that propranolol in infants with congenital heart disease not only decrease highly elevated NT-Pro-BNP values but also decrease cardiac troponin T values that may indicate myocardial injury due to neurohumoral activation. We reproduce this observation, primarily seen in infants with congenital heart disease, in an infant with Duchenne muscular dystrophy. These observations were in good accordance with current data from H. Liu et al., who showed that treatment with non-selective beta blockers early after birth might rescue cytokinesis defects and prevent heart dysfunction in adulthood in a mouse model.
%K Heart Failure
%K Congenital Heart Disease
%K Duchenne Muscular Dystrophy
%K Pro-pranolol
%K Carvedilol
%K Cardiac Troponin T
%K Myocardial Injury
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=106385