%0 Journal Article
%T Development and validation of HPLC method for the analysis of bifenox in
bulk and commercial dosage forms
%J -
%D 2016
%X A simple, economic, selective, precise, and accurate High Performance liquid Chromatographic method for the analysis of Bifenox in bulk and commercial formulations was developed and validated in the present study. The mobile phase consists of a mixture of Acetonotrile and water in proportion 50:50 and adjust the pH to pH to 6.0 ¡À 0.05 with sodium hydroxide solution. This was found to give a sharp peak of Bifenox at a retention time of 3.637min. HPLC analysis of Bifenox was carried out at a wavelength of 300 nm with a flow rate of 1.0 mL/min. The linear regression analysis data for the calibration curve showed a good linear relationship with a regression coefficient of 0.999 in the concentration range of 50 ¦Ìg ml-1 to 150 ¦Ìg ml-1. The linear regression equation was y = 3416x- 124.4. The developed method was employed with a high degree of precision and degradation for the analysis of Bifenox. The developed method was validated for precision, robustness, detection and quantification limits as per the ICH guidelines. The wide linearity range, sensitivity, short retention time and composition of the mobile phase indicated that this method is better for the quantification of Bifenox
%K B. Ravi
%U https://www.imedpub.com/abstract/development-and-validation-of-hplc-method-for-the-analysis-of-bifenox-inrnbulk-and-commercial-dosage-forms-11607.html