%0 Journal Article
%T C-Type of Natriuretic Peptide and Progenitor Endothelial Cell Dysfunction: The
Link to Heart Failure Development
%A er E Berezin
%J -
%D 2017
%X C-type of natriuretic peptide (CNP) is a promising   biomarker of heart failure (HF) development and HFrelated   clinical outcomes. Recent clinical studies have   shown that elevated level of CNP strongly related to   cardiac hemodynamic overload, myocardial ischemic   injury, endothelial dysfunction, early atherosclerorsis, and   worsening vascular repair. Whether CNP plays a   regulatory role in restoring endothelium structure and   function through modulating repair capacity of   endothelial progenitor cells (EPCs) is not fully clear.   However, CNP counteracts angiotensin II, which mediates   NF-kappaB-dependent pro-inflammatory genes,   peroxisome proliferator-activated receptor-¦Á and ¨C¦Ã   genes, NADPH/NADH oxidase genes in EPCs, deficiency of   which is considered a marker of HF development and   advance. The aim of the short comment is to discuss the   role of CNP as mediator of vascular reparation and a marker of restoring of endothelial function in HF patients
%K Alexander E Berezin
%K Heart failure
%K C-type of natriuretic peptide
%K Progenitor endothelial cell
%K Biomarkers
%U https://www.imedpub.com/abstract/ctype-of-natriuretic-peptide-and-progenitor-endothelial-cell-dysfunction-thernlink-to-heart-failure-development-18925.html