%0 Journal Article
%T Indicators of Vascular Dysfunctions in Children with End Stage Renal Disease under Regular Haemodialysis as Paediatric Emergency
%J -
%D 2017
%X Background: There is a necessity to predict cardiovascular   diseases in children with end stage renal disease (ESRD)   on regular haemodialysis. Objectives: to study   biochemical, structural and functional indicators of   vascular dysfunction in children with ESRD on regular   haemodialysis (HD) and their correlations as early predictors of cardiovascular diseases in dialysis children.
Materials and methods: The present study was carried   out on 30 children with ESRD on regular hemodialysis in   Tanta University hospital and 30 healthy age and sex   matched children as controls. All patients and control   were subjected to history taking, clinical examination   including, routine laboratory assessment measuring   serum cholesterol, serum calcium and phosphorous, Ca ¡Á   P product, serum alkaline phosphatase and serum intact   parathyroid hormone (iPTH). Radiological assessment was   done using B-mode ultras-onography to assess arterial   calcifications, arterial stiffening by measuring mean CCA   diameter in mm, carotid intima media thickness (CCA-IMT in ¦Ìm), aortic PWV in cm/sec, Renal Resistance Index.
Results: Twelve (80%) of the studied patients showed   calcifications in one or more of the studied different sites.   There was a highly significant increase in the CCA   diameter, CCA-IMT and Ao. PWV in studied patients as   compared to the controls but there was no significant   difference between patients and controls as regard renal RI (P>0.05).
Conclusion: Vascular calcifications in children with ESRD   on regular haemodialysis are associated with increased   stiffness of large, arteries. The extent of arterial   calcification increases mainly with the duration of dialysis and abnormalities in Ca ¡Á P product
%K Mohamed A El-Gamasy
%K Atherosclerosis
%K Children
%K Haemodialysis
%K Chronic
%K Renal
%U https://www.imedpub.com/abstract/indicators-of-vascular-dysfunctions-in-children-with-end-stage-renal-disease-under-regular-haemodialysis-as-paediatric-emergency-20320.html