%0 Journal Article
%T Increasing growth rate slows adaptation when genotypes compete for diffusing resources
%A Allison K. Shaw
%A Jeremy M. Chac¨Žn
%A William R. Harcombe
%J -
%D 2020
%R 10.1371/journal.pcbi.1007585
%X The rate at which a species responds to natural selection is a central predictor of the speciesĄ¯ ability to adapt to environmental change. It is well-known that spatially-structured environments slow the rate of adaptation due to increased intra-genotype competition. Here, we show that this effect magnifies over time as a species becomes better adapted and grows faster. Using a reaction-diffusion model, we demonstrate that growth rates are inextricably coupled with effective spatial scales, such that higher growth rates cause more localized competition. This has two effects: selection requires more generations for beneficial mutations to fix, and spatially-caused genetic drift increases. Together, these effects diminish the value of additional growth rate mutations in structured environments
%K Genetic drift
%K Simulation and modeling
%K Polygons
%K Evolutionary adaptation
%K Evolutionary rate
%K Variant genotypes
%K Batch culture
%K Evolutionary genetics
%U https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007585