%0 Journal Article
%T Seroprevalence of EV-A71 neutralizing antibodies following the 2011 epidemic in HCMC, Vietnam
%A Fang-Lin Kuo
%A Le Nguyen Thanh Nhan
%A Le Quoc Thinh
%A Min-Shi Lee
%A Nguyen Thanh Hung
%A Shu-Ting Luo
%A Truong Huu Khanh
%A Wan-Yu Chung
%A Wen-Chiung Chang
%J -
%D 2020
%R 10.1371/journal.pntd.0008124
%X Enterovirus-A71 (EV-A71) cyclically causes hand-foot-mouth disease (HFMD) epidemics in Asian children. An EV-A71 epidemic occurred in Southern Vietnam in 2011, but its scale is not clear. We collected residual sera from non-HFMD Vietnamese inpatients in 2012¨C2013 to determine seroprevalence of EV-A71 neutralizing antibodies, and measured cross-reactive neutralizing antibody titers against three EV-A71 genogroups. About 23.5% of 1-year-old children in Southern Vietnam has been infected by EV-A71, and the median age of infection was estimated to be 3 years. No significant antigenic variation could be detected among the three EV-A71 genogroups. The high seroprevalence of EV-A71 neutralizing antibody in children living in southern Vietnam indicates the necessity of introducing EV-A71 vaccines in southern Vietnam, particularly for children under 6 months of age. Moreover, it is critical to understand EV-A71 disease burden for formulating national vaccination policy
%K Antibodies
%K Vietnam
%K Inpatients
%K Asia
%K Hand
%K foot and mouth disease
%K Taiwan
%K Infectious disease epidemiology
%K Respiratory infections
%U https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008124