%0 Journal Article
%T Antibody-mediated neutralization of ACBP/DBI has anorexigenic and lipolytic effects
%A Guido Kroemer
%A Isabelle Martins
%A Jos¨¦ M. Bravo-San Pedro
%A Omar Moti£¿o
%A Valentina Sica
%J Adipocyte
%D 2020
%R https://doi.org/10.1080/21623945.2020.1736734
%X ABSTRACT We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel ¡®hunger factor¡¯: a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and obesity. Conversely, neutralization of ACBP/DBI by systemic injection of neutralizing monoclonal antibodies or autoantibodies produced after auto-immunization against ACBP/DBI has anorexigenic and lipolytic effects. Thus, neutralization of ACBP/DBI results in reduced food intake subsequent to the activation of anorexigenic neurons and the inactivation of orexigenic neurons in the hypothalamus. Moreover, ACBP/DBI neutralization results into enhanced triglyceride lipolysis in white fat, a surge in free fatty acids in the plasma, enhanced incorporation of glycerol-derived carbon atoms into glucose, as well as an increase in ¦Â-oxidation, resulting in a net reduction of fat mass. Importantly, ACBP/DBI neutralization also stimulated an increase in autophagy in various organs, suggesting that it might mediate anti-ageing effects
%U https://www.tandfonline.com/doi/full/10.1080/21623945.2020.1736734