%0 Journal Article
%T LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis
%A Di Wang
%A Di Zhao
%A Ketong Liu
%J Bioengineered
%D 2020
%R https://doi.org/10.1080/21655979.2019.1704535
%X ABSTRACT This study is aimed to explore the roles of LINC00528 in myocardial infarction (MI) progression. Quantitative real-time PCR showed that the expression of LINC00528 and COX-2 was upregulated while miR-143-3p expression was down-regulated in post-MI cells. In function assays, LINC00528 suppression promoted post-MI cells proliferation and reduced cell apoptosis in vitro. In mechanism, LINC00528 interacted with miR-143-3p in post-MI cells. COX-2 served as a target of miR-143-3p in post-MI cells. Besides, LINC00528 inhibition on COX-2 expression and post-MI cells progression could be partially abolished by miR-143-3p inhibitors. Therefore, our findings suggested that LINC00528 exerted its regulatory roles in MI via the miR-143-3p/COX-2 axis, which provided a potential therapeutic target for MI patients treatment. Graphical abstrac
%U https://www.tandfonline.com/doi/full/10.1080/21655979.2019.1704535