%0 Journal Article
%T Glucose-lowering Effect for Low Carbohydrate Diet (LCD) in Diabetic Patients with Positive Glutamic Acid Decarboxylase Antibody (GADA)
%A Hiroshi B
%A Koji Ebe
%A Masahiro B
%A Yoshikazu Yonei
%J -
%D 2019
%X Background: Authors and collaborators have continued
  clinical research for Low Carbohydrate Diet (LCD) and
  Calorie Restriction Diet (CRD), glucose variability and M
  value. We investigated patients with Type 2 Diabetes
  Mellitus (T2DM) with positive Glutamic Acid Decarboxylase
  Antibody (GADA).
Subjects and methods: Subjects were 12 patients with
  T2DM showing positive GADA (group 1). They were given
  CRD on day 1,2, and LCD on day 3-14. Daily profile of blood
  glucose was measured each day, and data were calculated
  to M value expressing average glucose and Mean Amplitude
  of Glycemic Excursions (MAGE). Further, 12 T2DM cases
  with negative GADA were recruited, who were age-, sexglucose-
  related data-matched (group 2).
Results: Data of group 1 were as follows: age 54.9 ¡À 14.3 yo,
  HbA1c 7.1 ¡À 0.9%, average blood glucose and M value on
  day 2 vs 4 were 187 (157-255) vs 145 (114-172), 76.9
  (45.9-278) vs 27.2 (19.3-83.5), respectively. In group 2, M
  value on day 2 vs 4 were 69.9 (37.8-149) vs 5.8 (3.5-13.3),
  respectively. Group 1 showed insufficient decreased glucose
  in M value.
Discussion and conclusion: These results suggested that
  cases with positive GADA would have insufficient insulin
  secretion in response to LCD, and may lead to Slowly
  Progressive Insulin-Dependent Diabetes Mellitus (SPIDDM)
  status in the future
%K Koji Ebe
%K Hiroshi Bando
%K Tetsuo Muneta
%K Masahiro Bando and Yoshikazu Yonei
%K Glutamic acid decarboxylase antibody (GADA)
%K Slowly-progressive type 1 diabetes (SPIDDM)
%K Glucose variability Type 2 diabetes mellitus (T2DM)
%K M value Low Carbohydrate Diet (LCD)
%U https://www.imedpub.com/abstract/glucoselowering-effect-for-low-carbohydrate-diet-lcd-in-diabetic-patients-with-positive-glutamic-acid-decarboxylase-antibody-gada-24419.html