%0 Journal Article
%T Antioxidant Activity Evaluation in a Series of Heterocyclic Compounds Derived from 1,8-Diaminonaphthalene
%A Tuo Nanou Ti¨¦ba
%A Kangah Niameke Jean Baptiste
%A Ballo Daouda
%A Kablan Ahmont Landry Claude
%A Kodjo Charles Guillaume
%A Yapo Ossey Bernard
%A Ziao Nahoss¨¦
%J Journal of Biophysical Chemistry
%P 1-9
%@ 2153-0378
%D 2021
%I Scientific Research Publishing
%R 10.4236/jbpc.2021.121001
%X From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl,
the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring,
allows us to synthesize the studied compounds. These three compounds have been characterized by conventional
spectroscopic methods (NMR and MS). The interest of this work is to review the
antioxidant activity of our compounds. The antioxidant activity screening carried
out according to FRAP and DPPH methods revealed significant anti-free radical
properties for compounds 1 and 2 even at low concentrations. In contrast to the
compound 2, compound 3 for which the OH group is substituted in <i>para</i> position has the lowest activity in both cases. Therefore the <i>para</i> position seems to be the least
sensitive position to increase the antioxidant activity of this pharmacophore.
%K Perimidine
%K Spectrometry
%K Antioxidant Activity
%K 2
%K 2-Diphenyl-1-Picrylhydrazyl Method and Ferric Reducing  Antioxidant Power Method
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=107125