%0 Journal Article
%T Cystatin C Peptide Effects on B16F10 Melanoma Cells
%A Mathieu Hill
%A James L. Cox
%J CellBio
%P 1-9
%@ 2325-7792
%D 2021
%I Scientific Research Publishing
%R 10.4236/cellbio.2021.101001
%X <strong>Background</strong>: Metastasis is a major problem for effective therapy of cancer. Small cysteine protease inhibitors, cystatins have been shown to be anti-metastatic for a number of different cancers. We have identified a small peptide of cystatin which exhibits anti-cancer properties for B16 melanoma cells in vitro. <strong>Methods</strong>: B16 melanoma cells were measured for growth, proliferation, migration, and apoptosis in the presence and absence of cystatin peptide. <strong>Results</strong>: The cystatin peptide reduced melanoma cell growth, proliferation, migration, and increased apoptosis in melanoma cells in culture. <strong>Conclusion</strong>: Cystatin peptide exhibits anti-cancer effects on highly metastatic B16 melanoma cells in culture.
%K Cystatin
%K Peptide
%K Melanoma
%K Metastasis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=107772