%0 Journal Article
%T Cytotoxicity of Mongolian Medicine <i>Aconitum kusnezoffii</i>
%A Xiong Su
%A Xiaoyu Gao
%A Lijuan Shang
%A Zhiqiang Li
%A Wancheng Zhao
%A Baofeng Chi
%A Shiqi Wang
%A Hairong Zhang
%A Dejun Sun
%A Juan Sun
%J Chinese Medicine
%P 10-18
%@ 2151-1926
%D 2021
%I Scientific Research Publishing
%R 10.4236/cm.2021.121002
%X <i><span style=\"font-family:Verdana;\">Aconitum kusnezoffii</span></i><span style=\"font-family:Verdana;\"></span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\"> used as an analgesic and anti-inflammatory. It is often used not only in
Mongolian medicine but also in traditional Chinese medicine. However, there are
few studies on its impact of inflammatory cytokines. This study explored the
effects of </span><span style=\"font-family:Verdana;\"><i></i></span><i><i><span style=\"font-family:Verdana;\">Aconitum kusnezoffii</span></i> <i><span style=\"font-family:Verdana;\">in vitro</span></i><span style=\"font-family:Verdana;\"></span></i></span><span style=\"font-family:Verdana;\"> used human colon cancer (Caco-2)
cells. Cytotoxicity was assessed by measuring effects on expression of IL-1</span><i><span style=\"font-family:Verdana;\"><span style=\"white-space:nowrap;\">¦Â</span></span></i><span style=\"font-family:Verdana;\">, IL-6, IL-8, and TNF-</span><i><span style=\"font-family:Verdana;\"><span style=\"white-space:nowrap;\">¦Á</span></span></i><span style=\"font-family:Verdana;\"> used enzyme-linked immun</span><span style=\"font-family:Verdana;\">o</span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">sorbent assay (ELISA). </span><span><span style=\"font-family:Verdana;\"><i></i></span><i><i><span style=\"font-family:Verdana;\">In vitro</span></i><span style=\"font-family:Verdana;\"></span></i></span></span><span style=\"font-family:Verdana;\"> study demonstrated that incubation of Caco-2 cells with some kinds of</span><i> </i><span style=\"font-family:Verdana;\"><i></i></span><i><i><span style=\"font-family:Verdana;\">Aconitum kusnezoffii</span></i><span style=\"font-family:Verdana;\"></span></i><span style=\"font-family:Verdana;\"> at some concentrations
inhibit secretion of TNF-</span><i><span style=\"font-family:Verdana;\"><span style=\"white-space:nowrap;\">¦Á</span></span></i><span style=\"font-family:Verdana;\"> and FAXIU </span><span style=\"font-family:Verdana;\"><i></i></span><i><i><span style=\"font-family:Verdana;\">ACONITUM</span></i> <i><span style=\"font-family:Verdana;\">KUSNEZOFFII</span></i><span style=\"font-family:Verdana;\"></span></i><span style=\"font-family:Verdana;\"> could inhibit the secretion of IL-1</span><i><span style=\"font-family:Verdana;\"><span style=\"white-space:nowrap;\">¦Â</span></span></i><span style=\"font-family:Verdana;\">.
While IL-6 and IL-8 levels were unaffected after 24 h of treatment with </span><span
%K &lt
%K i&gt
%K Aconitum kusnezoffii&lt
%K /i&gt
%K Cytotoxicity
%K Proinflammatory Cytokines
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=107973