%0 Journal Article
%T Utility of amino acid coupled 1,2,4-triazoles in organic synthesis: synthesis of some new antileishmainal agents
%A A. M. Kadry
%A A. M. M. El-Saghier
%A M. A. A. Mohamed
%A O. A. Abdalla
%J -
%D 2018
%X Starting from 3-amino-5-(2-hydroxyphenyl) amino acid coupled triazoles 1a-e, new 3-(2-hydroxyphenyl)-3H-imidazo[2,1-c][1,2,4]triazol-6(5H)-one 2a,b, 3b,d, 6a and 3-N-arly(alkyl) amino acid coupled triazoles 4b,d, 7a,c,d,e have been synthesized as potential antileishmanial agents. The structures of the newly synthesized compounds were confirmed using elemental and spectral analyses (FT-IR, 1H-NMR, 13C-NMR and MS). The in vitro antileishmanial potency of the synthesized compounds was evaluated compared to Amphotericin B deoxycholate and miltefosine as lead references. Compounds 2b, 7d and 7e showed perfect IC50 values corresponding to amphotericin B and more patent than miltefosine against L. aethiopica promastigotes.
%U https://www.ajol.info/index.php/bcse/article/view/180058