%0 Journal Article
%T Multi component one pot synthesis and characterization of derivatives of 2-amino-7,7- dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile and study of anti-microbial activity
%A B. Parvatamma
%A K. P. Devi
%A N. K. Rao
%A S. C. Setty
%A T. N. Rao
%J -
%D 2018
%X An efficient and convenient procedure has been described for one-pot multi-component synthesis
%K of tetrahydrobenzo[b]pyrans known as 2-amino-7
%K 7-dimethyl-5-oxo-4-phenyl-5
%K 6
%K 7
%K 8-tetrahydro-4H-chromene-3-carbonitrile which can be obtained from the reaction of substituted aromatic aldehydes
%K dimedone
%K malonitrile
%K in the presence of base such as potassium tertiary butoxide and THF in methanol as solvent at RT condition. All the compounds were examined by advanced spectroscopic data (1H NMR
%K 13C NMR and LCMS) and the structural determination was evaluated by elemental analysis. In addition to this
%K all the newly synthesized compounds were examined for their antibacterial activities and antifungal activity by disc diffusion method against the organism of Aspergillus niger and Candida ablicans L.
%U https://www.ajol.info/index.php/bcse/article/view/169540