%0 Journal Article
%T Sacran, a High-molecular Weight Polysaccharide Inhibits Renal Injury and Oxidative Stress in Chronic Renal Failure Model Rats
%A Anraku
%A Arima
%A Daisuke
%A Fumitoshi
%A Goto
%A Hidetoshi
%A Higashi
%A Hirayama
%A Iohara
%A Kaneko
%A Kaneto
%A Keiichi
%A Makoto
%A Maruyama
%A Masaki
%A Miwa
%A Motoyama
%A Otagiri
%A Shinichiro
%A Taishi
%A Toru
%A Uekama
%J -
%D 2018
%R 10.18314/jnb.v4i2.1380
%X The administration of a high-molecular polysaccharide Sacran results in a significant decrease in renal injury and oxidative stress, compared with that for the oral carbonaceous adsorbent, AST-120 (Kremezin£¿) or a non-treatment group in 5/6 nephrectomized rats. An oral administration of Sacran (20 mg/day) over a 4 week period resulted in a significant decrease in serum indoxyl sulfate, creatinine and urea nitrogen levels, compared with a similar treatment with AST-120 or the non-treatment group. Sacran treatment also resulted in antioxidant potential being maintained, compared with that for AST-120 or the non-treatment group. Immuno-histochemical analyses also demonstrated that CRF rats, when treated with Sacran, showed a decrease in the level of accumulated renal fibrosis and 8-OHdG compared with AST-120 or the non-treatment group. These results suggest that the ingestion of Sacran results in a significant reduction in the levels of prooxidants, such as uremic toxins, in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation
%K nutrition research journals
%K journal of nutritional biology
%K open access nutrition journals
%K food sciences impact factor list
%K nutrition research papers
%U https://www.gratisoa.org/journals/index.php/GJFN/article/view/1380